Relief Factor Reviews, Ingredients, Does It Work?

Edited and medically reviewed by ✔️ Team of BestInSupplements | Written by Katelyn Johnson (B.S. and M.S. in Nutrition Science)

Wondering if there’s a natural way to relieve pain? Learn how Relief Factor can be your first choice as a holistic pain-relief remedy by reading our review of its ingredients, safety, uses, and benefits.

Review of Relief Factor

Physical stressors from everyday life can cause aches and pains all over our bodies, especially as we get older. Whether the pain is caused by age, exercise, or just everyday life, it's critical to know what's causing it and how to fix it. Nebula Genomics Relief Factor is a drug-free botanical and fish oil supplement created to help people cope with pain.

Relief Factor was formulated in a clinical setting with a distinct herbal blend and marketed as an anti-inflammatory supplement that alleviates muscle and joint pain commonly associated with aging and excessive exercise 1.

What sets Relief Factor apart is the fact that this supplement concentrates on the body's top four metabolic pathways and addresses the underlying issues that cause inflammation. Relief Factor is intended to be used over a long period of time, as the company claims that the product's usefulness and beneficial effects will improve over time after consistent use.

Relief Factor Benefits

Relief Factor is a pain-relieving supplement made with a combination of natural and organically-sourced ingredients known for having anti-inflammatory capabilities 1. By supplementing with the Relief Factor supplement, users experience reductions in inflammation, joint stiffness, discomfort, and joint aches.

Fights Inflammation

Relief Factor improves the user's inflammatory response by working on the way in which the body interprets unpleasant signals. The ingredients also play a role in modifying the body's gene expression for joint pain response. In doing so, this creates an environment where the body can effectively heal and restore itself. It therefore reduces inflammation, which relieves aches and pain at their sources, while also restoring flexibility and mobility 1.

Relieves Inflammatory-induced Conditions

Relief Factor helps your body cope with the aches and pains that come with aging, exercise, and living a sedentary lifestyle. It works in tandem with the body's overall plan to combat inflammation to relieve nerve pain 1. Additionally, because Relief Factor is an anti-inflammatory supplement, it can help with joint pain and relieve symptoms caused by arthritis.

Boosts Immunity

It also contains a lot of antioxidants, which help the body's immune system and natural joint pain response 1.

Improves Heart Health

Blood flow is essential for maintaining good health, but it decreases as you age. Turmeric, a key ingredient in Relief Factor, improves blood flow and protects your organs. You will also experience an increase in your energy levels 2.

Relief Factor Ingredients

Ingredients of Relief Factor

Relief Factor contains a combination of natural ingredients with unique functions that support the body's natural response to inflammation in order to help to eliminate age-related and exercise-related pains in the most natural way possible.

The four major active ingredients include Turmeric, Omega 3 fatty acids (EPA and DHA), Resveratrol, and Icariinc.


Turmeric has been used for thousands of years as a spice and medicinal herb. It has recently been investigated for its antioxidant and anti-inflammatory properties. Turmeric appears to have anti-inflammatory properties that are comparable to, if not superior to, prescription or over-the-counter medications 2.

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Turmeric was found to be even more effective than medication at reducing pain and tenderness in people with active rheumatoid arthritis in one study 2. A 2019 meta analysis found that taking 1,000 mg of turmeric per day minimized osteoarthritis pain and inflammation, without the need for additional support, including NSAIDs like diclofenac and ibuprofen 3.


Anti-inflammatory properties of omega-3 fatty acids have long been recognized. Omega-3 supplementation has been shown in studies to minimize the synthesis of chemical compounds linked to inflammation in the body 4. Numerous studies have looked into the use of fish oil supplements to prevent heart disease, diabetes, and other inflammatory conditions 5.

Fish oil contains two types of omega-3 fatty acids: EPA and DHA. Inflammation, which causes swelling and pain, can be reduced by both EPA and DHA. Omega-3 fatty acids were observed to decrease morning stiffness, as well as tender and swollen joints, in rheumatoid arthritis patients in one study. The participants in this study were also able to decrease their pain medication consumption 6.

Supplementing with omega-3 fatty acids was shown to mitigate pain in individuals with arthritis. Omega-3 supplementation may also have some additional health benefits, such as reducing chronic diseases, due to its ability to reduce systemic (whole-body) inflammation 7.


Resveratrol is an antioxidant-like substance present in berries and grapes' skins and seeds. This compound contains Japanese Fleeceflower, which has the primary function of promoting healthy blood flow and supporting vessel health.

Resveratrol helps protect cartilage from deterioration in people with arthritis when taken as a supplement, according to research 8. Studies also claim that resveratrol has significant joint-protective effects for individuals with osteoarthritis and rheumatoid arthritis 8.


Icariin is an active compound with beneficial anti-inflammatory properties that has been linked to a number of positive health effects. These include anti-aging, anti-atherosclerosis, and even antidepressant properties in addition to providing therapeutic relief for these medical conditions 9. The main compound in Icariin, Epimedium, has been studied exclusively and shown to assist in inflammatory responses, as well as improving blood flow and tissue health 9.

Icariin had a clinically significant therapeutic impact in patients with rheumatoid arthritis, according to one study. In a study with rabbits, it was shown to protect cartilage and bone from deterioration 19.

Relief Factor Safety and Side Effects

There's no reason to think Relief Factor isn't safe because it's made entirely of drug-free botanical and fish products. Relief Factor has been on the market for a long time, and no one has ever complained about any negative side effects. If you look at the official website, you'll see that it's suggested that you start with three packets, or 12 capsules per day.

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Side effects such as dizziness, loose stool, and nosebleeds are common in the early stages of using Relief Factor, but they will fade over time. Fish oil can be irritating to some people, especially those who have sensitive stomachs. The side effects will be reduced if this formula is taken with food.

People who are taking blood thinners should also seek medical advice before starting this dosage. Some of the ingredients in this formula boost blood flow, causing unwanted interactions in the circulatory system. However, you should consult a doctor for specific instructions on how to use the supplement.

Relief Factor Reviews and Final Thoughts

The number of customer reviews for Relief Factor is quite impressive.

In one Relief Factor review, a customer described how they ordered the supplement to help with arthritis-related knee pain.  To their surprise, not only did this supplement for joint pain address the inflammation caused by lymphedema, but it also helped their leg shrink significantly and addressed arthritis in general with no side effects.

At the same time, the customer expressed regret for not taking the supplement sooner and stated that they will continue to order this supplement for long-term use.

If you're looking for a pain relief supplement for joint pain, flexibility, or protection against the wear and tear of old age, this formula should be tried in your diet.

Take a look at this list: The Best Keto Supplements You Can Buy

Relief Factor is an all-natural formula that relieves muscle pain and aches throughout the body. It's made with a combination of high-quality ingredients and anti-inflammatory agents to relieve pain and swelling. It's no secret, based on its customer reviews, that this product is of high quality and effective in treating inflammation-related pain.

Where to Buy Relief Factor

Relief Factor is only available from the manufacturer's official website and not from any independent online retail stores.

On the supplement's website, a month's supply costs around $95 plus shipping and handling.

You can, however, join the 3-Week QuickStart program and get your first order for around $20, followed by an $80 or so monthly auto-ship program.

It is advised that you place your order through the official website. Because of the nature of the supply mechanism, ordering from the official website will protect you from online scams and ensure that you receive the supplement on time.

Frequently Asked Questions

Relief Factor is a natural pain relief supplement that is designed to support the body’s natural inflammatory response to support joint health and general wellness. The supplement aims to help reduce the symptoms of pain- and inflammation-induced health conditions.
Relief Factor is formulated with natural ingredients to offer consumers a natural means to help them reduce symptoms associated with inflammation, swelling, and pain. The ingredients include omega 3 fatty acids, turmeric (curcuminoid), epimedium (Chinese herb), and Japanese Fleeceflower (resveratrol).
Relief Factor is viewed as safe to consume but not without potential side effects. These include loose stool, dizziness, and bloating. The formula contains a high concentration of fish oil so it may cause digestive distress in individuals who have a sensitive stomach.
Relief Factor is manufactured and distributed by Promedev LLC. Promedev LLC is a subsidiary of Longevity Medical Clinic and is located in Washington, United States. Relief Factor is manufactured in the United States within facilities that comply with the FDA’s current GMP guidelines.
Relief Factor is available at a few different price points. You can purchase a 3-week “QuickStart” from the manufacturers website for $19.95. After this trial period, you can sign up for a monthly subscription that automatically renews itself. The cost of this monthly package is $79.95.
You can buy Relief Factor directly from the manufacturer's website. This is the recommended purchase method as it ensures the consumer will receive an authentic product. Relief Factor is also available at various retailers but you might be subject to product scams.


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  2. Chandran, B., & Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy research : PTR, 26(11), 1719–1725.
  3. Shep, D., Khanwelkar, C., Gade, P., & Karad, S. (2019). Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials, 20(1), 1-11.
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  6. Rajaei, E., Mowla, K., Ghorbani, A., Bahadoram, S., Bahadoram, M., & Dargahi-Malamir, M. (2016). The effect of omega-3 fatty acids in patients with active rheumatoid arthritis receiving DMARDs therapy: double-blind randomized controlled trial. Global journal of health science, 8(7), 18.
  7. Hutchinson, A. N., Tingö, L., & Brummer, R. J. (2020). The potential effects of probiotics and ω-3 fatty acids on chronic low-grade inflammation. Nutrients, 12(8), 2402.
  8. Nguyen, C., Savouret, J. F., Widerak, M., Corvol, M. T., & Rannou, F. (2017). Resveratrol, potential therapeutic interest in joint disorders: a critical narrative review. Nutrients, 9(1), 45.
  9. Li, C., Li, Q., Mei, Q., & Lu, T. (2015). Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii. Life Sciences, 126, 57-68.
  10. Wei, C. C., Ping, D. Q., You, F. T., Qiang, C. Y., & Tao, C. (2016). Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis. Mediators of inflammation, 2016, 9529630.

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