The Best Detox Supplements You Can Buy

Edited and medically reviewed by ✔️ Team of BestInSupplements | Written by Katelyn Johnson (B.S. and M.S. in Nutrition Science)

We’ve covered the best detox supplements you can buy. Read this article to find out which detox supplements actually work (and which ones don't) and how you can use them.

Best Detox Supplements

Supportive detox supplements are a good way to help reboot your system if you want to increase vitality and overall health. While eating a nutrient-dense diet is critical, detoxing your body of toxins will help you look and feel better.

Toxins accumulate in your system throughout the year, including those from environmental pollutants, personal care products, pesticides, food preservatives, chemicals in tap water, and even stress 1.

You may find interesting this: The Best Water Pills You Can Buy

A full-body detox can have a significant impact by assisting with:

  • Strengthening the immune system.
  • Optimizing digestion and gut health.
  • Improving circulation.
  • Increasing energy levels.
  • Promoting better sleep quality.

Why Detox Is Necessary

Elimination is your body's main line of defense against toxins. The process is carried out by several organs:

  • Liver – filters impurities from your blood and breaks down food nutrients for your cells to use 2.
  • Kidneys – assist your liver by filtering waste from your blood and excreting it as urine 3.
  • Lungs – responsible for filtering and removing harmful substances from the air you breathe 4.
  • Intestines – destroys unwanted organisms and releases them from your system 5.

These elimination pathways normally function well, but the excessive strain that occurs when your body is overburdened with toxins can harm your organs and weaken normal detoxification processes.

The Best Detox Supplements You Will Find In The Market

You can support your hardworking organs as they carry out their essential detox functions by taking a detox supplement. Depending on your wants and needs, there are a variety of detox products to choose from that can help your body achieve whole-body wellness.

Best for Bloating: The Nue Co. Debloat+

Bloating can be triggered by incomplete/poor digestion, toxic overload, and an unbalanced good/bad gut microbiome ratio 6. Resident bacteria will digest what your body doesn’t, which produces gas and stomach distention. This is one of the reasons why digestive enzyme supplements like Debloat+ are so popular.

Review of The Nue Co. Debloat+

Debloat+ helps your body’s digestive enzymes break down foods, which is a critical stage of detoxification. Debloat by The Nue Co. was formulated to alleviate digestive problems, relieve short-term bloating, and improve long-term gut health. Additionally, this product can help with IBS symptoms, upset stomach, and gas retention.

Best Natural: Biocol Labs Detox - Something For A Detox Week

When it comes to detoxing, the most vital point to remember is: to avoid chemicals. Natural ingredients are always the most effective when detoxing. Because Biocol Labs’ is referred to as a "post-chemical pharmacy", the supplement called Something For A Detox Week is the ideal detox supplement as it assists in regulating and balancing liver function while removing additives, pollutants, and dietary excesses from your body.

Review of Biocol Labs Detox - Something For A Detox Week

Although we don't see or feel it, the liver tends to accumulate a lot of toxins. Biocol Labs formulated Something For A Detox Week with the cleansing qualities of chicory, artichoke, and choline, as well as citric acid and potassium to support your liver's natural cleansing abilities 7. After a week of using Biocols detox supplement, you will notice a significant difference in your weight.

Best Whole-Body Detox: Anatome Detox and Cleanse

Anatome Detox + Cleanse is a nutritional remedy made with a combination of potent natural botanicals designed to help the body's natural detox system process everyday toxins.

Review of Anatome Detox and Cleanse

To ensure better gut function and a stronger immune system, this blends gut cleansing ingredients, including chicory, turmeric, and milk thistle, work together to relieve stomach distress in the body. Milk thistle supplementation has been shown to improve liver function, which also helps reduce liver inflammation and damage 8.

Their detox supplement is highly recommended during stressful times and effectively assists users to manage their digestive pain and detox in a safe and long-term manner.

Best Fast Cleanse: Dr. Tobias Colon 14 Day Quick Cleanse

Cleanse your body from the inside out with Dr. Tobias Colon's 14 Day Quick Cleanse. Although finishing a cleanse can be quite challenging, this all-natural detox supplement program can help you achieve a complete and total body cleanse.

Review of Dr. Tobias Colon 14 Day Quick Cleanse

Toxins will be flushed and the intestinal tract will be cleansed, alleviating bloating and boosting energy levels. Probiotics and fiber are included in this formula to ensure a thorough cleanse while also replenishing the good bacteria in your gut 9.

You can trust this cleanse formula because it has been third-party tested for safety, purity, and effectiveness. And to achieve the desired results, you only need to take one to two capsules per day.

Most Potent: Candida Detox Cleanse Complex

With this potent herbal cleanser, you can restore balance to your gut health, improve digestion, and absorb more nutrients. With Candida Detox Cleanse Complex you'll be able to eliminate harmful candida overgrowth from your gut thanks to their powerful blend of herbs that includes the powerhouse oregano. This cleanse is also infused with probiotics, which will reintroduce beneficial gut bacteria in order to effectively restore balance to your gut microbiome.

Review of Candida Detox Cleanse Complex

Candida Detox Cleanse Complex is manufactured in the United States and made with only the purest, non-GMO herbal ingredients.

Most Stackable Cleanse: Colon Cleanser & Detox for Weight Loss

Use this stackable detox supplement for a full-body detox and cleanse with probiotics to help you rebalance your gut health. This cleanse is designed to be used in conjunction with other BioSchwartz supplements to help you better detox and improve your overall health.

Review of Colon Cleanser & Detox for Weight Loss from Bioschwartz

Each bottle of Colon Cleanser & Detox for Weight Loss contains a proprietary blend of detox and health support herbs that is all-natural and non-GMO. Probiotics restore balance and aid in the maintenance of gut health. Every product ensures purity and quality through third-party testing. This leading detox supplement is backed by a 100% money-back guarantee.

Best for Liver Cleanse: Best Liver Supplements with Milk Thistle

Best Liver Supplements with Milk Thistle is a natural all-in-one supplement that improves liver health and function. In addition to being an excellent liver cleanse supplement, it is also an all-around health-boosting supplement 8.

Review of Best Liver Supplements with Milk Thistle

Their proprietary herbal blend contains antioxidants to ensure a strong immune system, as well as other natural compounds that reduce bloating, increase blood flow, stimulate cell growth, and lower cholesterol and blood pressure 2.

Best Cleanse for Women: Best Detox Colon Cleanse Weight Loss Pills for Women

Total Women's Detox from Superstar Nutrition is an all-natural detox supplement that helps women detox completely. With this powerful detox program, you can flush out toxins and harmful chemicals while regaining optimum health and supporting weight loss.

Review of Superstar Nutrition Best Detox Colon Cleanse Weight Loss Pills for Women

This supplement has everything you need in their proprietary blend, including fiber, which has natural laxative properties that aid in detoxification and rebalancing gut health. You will also regain your healthy glow, reduce bloating, even increase weight loss efforts.

Learn more about anti-aging solutions: The Best Anti-Aging Supplements You Can Buy

Each gluten-free, non-GMO supplement is third-party tested to ensure quality and potency.

Best for Skin Detox: The Beauty Chef Cleanse

The Beauty Chef Cleanse Inner Beauty Essential helps your body detox naturally, resulting in clearer, smoother skin. Skin breakouts are often linked to stress and an unhealthy gut. This detox supplement might be the answer for those dealing with failed breakout clearing products that aren't producing marketed results.

Review of The Beauty Chef Cleanse

With The Beauty Chef Clease’s combination of supergreens, digestive enzymes, prebiotics, and probiotics, gut toxins will be effectively removed to improve skin imperfections 7.

Frequently Asked Questions

The best detox supplements are designed to support the body’s detoxification processes by stimulating the liver’s function to eliminate built-up toxins over time. Their nutrient-dense formulas provide vital nutrients that promote healthy digestion while reducing bloating, fatigue, and mental fog.
The main ingredients found in the formulas of the best detox supplements are generally all-natural, organic, and non-GMO nutrients that support healthy detoxification processes in the body. These include vitamins, minerals, antioxidants, herbal extracts, prebiotics, probiotics, digestive enzymes, and fiber.
There are several factors to consider when choosing the best detox supplements. Make sure to choose a brand that uses third-party labs to test their formulas for purity. Also, find a product that is manufactured according to the FDA’s cGMP standards.
The best detox supplements are available in a variety of forms. You will likely find them in capsule or tablet form, which are beneficial as they offer concentrated doses of the active components to support the detox processes. They are also available as teas or liquids.
Avoid detox supplements that do not have clinically-effective ingredients in their formulas. It’s recommended that you avoid brands with poor reputations and do not offer transparent labeling as this limits the possibility that the formulas contain harmful ingredients or unnecessary fillers.
When consumed as directed on the label, detox supplements are generally safe to consume by healthy individuals. There are some minor side effects one may experience in the first couple of days, including digestive distress, diarrhea, nausea, bloating, and fatigue.


  1. Aggarwal, A. (2019). Heal Your Body, Cure Your Mind: Leaky Gut, Adrenal Fatigue, Liver Detox, Mental Health, Anxiety, Depression, Disease & Trauma. Mindfulness, Holistic Therapies, Nutrition & Food (Vol. 1). Dr. Ameet Aggarwal ND.
  2. Sivakrishnan, S., & Kavitha, J. (2009). Herbal Drugs, Diet and Lifestyle Changes for Liver Diseases-A.
  3. Peate, I. (2021). The urinary system: key to maintaining homeostasis. British Journal of Healthcare Assistants, 15(5), 234-237.
  4. Hogan, B., & Tata, P. R. (2018). Cellular organization and biology of the respiratory system. Nature, 560, 377-381.
  5. Nowland, T. L., Plush, K. J., Barton, M., & Kirkwood, R. N. (2019). Development and function of the intestinal microbiome and potential implications for pig production. Animals, 9(3), 76
  6. Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009). Principles and clinical implications of the brain–gut–enteric microbiota axis. Nature reviews Gastroenterology & hepatology, 6(5), 306-314.
  7. Raja, R. R. (2016). Nutraceuticals and cosmeceuticals for human beings–an overview. American Journal of Food Science and Health, 2(2), 7-17.
  8. Hackett, E. S., Twedt, D. C., & Gustafson, D. L. (2013). Milk thistle and its derivative compounds: a review of opportunities for treatment of liver disease. Journal of veterinary internal medicine, 27(1), 10-16.
  9. Nelson-Dooley, C. (2019). Heal Your Oral Microbiome: Balance and Repair Your Mouth Microbes to Improve Gut Health, Reduce Inflammation and Fight Disease. Simon and Schuster.

Every editorial product is independently selected, though we may be compensated or receive an affiliate commission if you buy something through our links.