Nature Made B12 Reviews, Ingredients, Does It Work?

Edited and medically reviewed by ✔️ Team of BestInSupplements | Written by Katelyn Johnson (B.S. and M.S. in Nutrition Science)

Want a straightforward review of a brand leader in the supplement world? We discuss the benefits, safety, and ingredients of Nature Made’s B12 to help you decide if this is an ideal supplement for you.

Review of Nature Made B-12

If you've been feeling abnormally lethargic and weak, or unable to stay awake during the day, you might be questioning if you're obtaining enough vital nutrients, including Vitamin B12, which is a key factor in energy production 1. For those who want to avoid a deficiency and the effects it has on overall health may find it extremely beneficial to supplement with a product like Nature Made Vitamin B12.

Vitamin B12 is a necessary nutrient that your body cannot produce on its own. Because Vitamin B levels are not typically checked during routine blood work, you could easily be one of the 15% of people who are vitamin B12 deficient or one of the nearly 40% who are borderline 2.

This review is part of: The Best B12 Supplements You Can Buy

Supplementing with a product like Nature Made Vitamin B12 is a great way to ensure your body has adequate levels of this essential nutrient, shown to improve immunity and energy levels, while also supporting a healthy functioning nervous system 1.

Nature Made B12 Benefits

Vitamin B12 does more than boost energy levels. Some of its most important functions include the production of red blood cells, the synthesis of DNA and RNA, and the development and maintenance of healthy functioning nerve cells. Because of its role in cell production, vitamin B12 also promotes healthy hair, skin, and nails 3.

Improves Energy Levels

You may be deficient in vitamin B12 if you tire easily or feel weak after minimal physical exertion. To understand why this is the case, you must first understand how blood works. Blood, specifically red blood cells (RBCs), aid in the transportation of oxygen throughout your body.

When you don't have enough oxygen, even simple tasks like walking up a flight of stairs seem to take a lot of energy. Vitamin B12 aids in the production of RBCs, which are required to keep oxygen circulating and to keep you from over-exhaustion 4.

Improve Symptoms of Depression

If your body has enough Vitamin B12 stores, you will be able to fight depression more effectively. Vitamin deficiencies in general have a tendency to exacerbate anxiety and depression. People who are suffering from these conditions would benefit greatly by taking Nature Made Vitamin B12 5.

Boosts Immunity

B12 plays an important role in the immune system by increasing the number of white blood cells. White blood cells are involved in the body's defense against infectious disease and foreign invaders. With a depressed immune system, pathogens are more likely to enter your system when your white blood cell count is low 6.

Cancer Fighting Properties

This vitamin's presence in the body acts as a protective mechanism against various types of cancer, and it is now being studied alongside folate for this purpose. Essentially, its presence both prevents and aids in the treatment of various cancers such as breast cancer, lung cancer, prostate cancer, and a few others. So, by taking a vitamin B12 supplement, you are protecting yourself from such diseases 7.

Heart Disease Prevention

Biologically speaking, Vitamin B12 is beneficial to the cardiovascular system as a whole 8.

According to research, vitamin B12 helps to lower homocysteine levels, which are thought to be a major risk factor for heart disease. Researchers have demonstrated that a vitamin B12 deficiency is common in people who suffer from heart disease 8.

Suffice it to say, taking Vitamin B12 could go a long way toward keeping your heart healthy and strong, preventing heart disease.

Neurological Disease Prevention

According to research, B12 may also play a significant role in the prevention of Alzheimer's disease 9.This disease, which has long been a mystery, still has no cure or scientific procedure to eradicate the disease.

That said, we can certainly take precautions – like supplementing with Nature Made B12 - to avoid it in the future. If you have a family history of this disease or other similar neuropsychiatric disorders, you may find keeping this supplement on hand advantageous 9.

Supports Hair, Skin, and Nails

Vitamin B12 helps in prevention and treatment of skin conditions such as blemishes, acne, and dryness 10. Similarly, vitamin B12 helps to make your hair look shinier and healthier, as well as improving the structure and appearance of nails 11.

Nature Made B12 checks all the boxes: it's third-party tested to ensure label accuracy — a rare occurrence for these types of supplements — it's made in a GMP-certified facility, it's vegetarian friendly, and it's surprisingly affordable. They are also time released, which means they digest slowly and release into the bloodstream throughout the day.

Nature Made B12 Ingredients

Ingredients of Nature Made B12

Even if the ingredients of Nature Made B12 supplement may vary depending on the form you will be buying (they are available in gummies, lozenges, tablets and softgels), the main ingredient you will find on all of them includes Vitamin B12 as Cyanocobalamin.

Nature Made B12 can be found in the following forms of products:

  • Gummies, commercialized as Daily Energy Gummies and Energy B12 1000 mcg Gummies.
  • Lozenges, commercialized as Vitamin B12 Sublingual 1000 mcg Lozenges and Vitamin B12 Sublingual 3000 mcg Lozenges.
  • Tablets, commercialized as Vitamin B12 500 mcg Tablets, Vitamin B12 Time Release 1000 mcg Tablets, and Vitamin B12 Extra Strength 2500 mcg Tablets.
  • Softgels, commercialized as Vitamin B12 1000 mcg Softgels, Vitamin B12 Extra Strength 3000 mcg Softgels, and Maximum Strength 5000 mcg Vitamin B12 Softgels.

Who Should Buy Nature Made B12?

Vegans and vegetarians are more likely to be deficient in B12 than meat eaters because vitamin B12 can only be found in animal products 12.

Luckily, it's very easy to supplement. So, if you are following a vegetarian or vegan diet, you should consider taking a B12 supplement. Also, people over the age of 50 are at risk of b12 deficiency 12.

Nature Made B12 Safety and Side Effects

Cyanocobalamin, which is a chemically synthesized form of B12, is the most common form of B12 found in supplements, like Nature Made B12 1000 13. If you are given a high-dose vitamin B12 supplement to treat a deficiency, you may experience some minor side effects, like:

  • Diarrhea
  • Nausea or upset stomach
  • Itching or rash
  • Headache
  • Dizziness
  • Weakness
  • Numbness or tingling
  • Fever
  • Joint pain
  • A feeling of swelling all over the body

Cyanocobalamin B12 supplements may result in low potassium levels in the blood. If you experience muscle cramps or an irregular heartbeat after taking vitamin B12, consult your doctor 13.

Nature Made B12 Reviews and Final Thoughts

Nature Made is an all-around excellent supplement company. When it comes to their B12 supplement, many buyers state they experience the best results with the time-release product.

According to customer reviews, the Nature Made Vitamin B12 supplement gave them an energy boost after only a few days of use. Reviewers also say it has helped them improve their memory. This product is also described by reviewers as high-quality and beneficial for a variety of conditions, including weaning off antidepressants or anti-anxiety medications.

Learn More About This Brand: The Nature Made Supplements You Should Buy

The soft gels are easy to swallow and have little to no aftertaste. They are simple to incorporate into your daily routine—even if you aren't typically a supplementer.

Where to Buy Nature Made B12

Nature Made 1000 mcg Vitamin B12 Softgels, which is one of the most populars forms of this B12 supplement in the softgels’ category, is available for purchase at nearly every retail store that sells supplements, or online through Amazon.

In general, pricing breaks down to:

150 Count for around $16 (roughly $0.10/count)
90 Count for around $14 (roughly $0.17/count)

It can be also bought in the form of Vitamin B12 Extra Strength 3000 mcg Softgels, and Maximum Strength 5000 mcg Vitamin B12 Softgels. The price of each one of them starts at around 15 and 16 dollars, respectively.

Nature Made B12 is also available in the form of gummies, lozenges, and tablets. The prices of each category starts at:

  • Gummies:
    • Daily Energy Adult Gummies 70 Gummies, starting at around $10.
    • Energy B12 Adult Gummies 80 Gummies, starting at around $15.
  • Lozenges:
    • Vitamin B12 1000 mcg. 50 Lozenges, starting at around $8.
    • Vitamin B12 3000 mcg. 40 Lozenges, starting at around $13.
  • Tablets:
    • Vitamin B12 500 mcg. 100 Tablets, starting at around $8.
    • Vitamin B12 1000 mcg. 75 Tablets, starting at roughly $22.
    • Vitamin B12 2500 mcg. 60 Tablets, starting at about $14.
Nature Made
Nature's Made products are free of contaminants and toxins as they are produced by following all safety protocols and settings. Nature Made supplements are the number 1 recommended brand by pharmacists because of their health benefits, efficacy, and potency.

Frequently Asked Questions

Nature Made B12 is a time-release vitamin B12 health tablet supplement that aids in the energy production from food to provide energy for cellular processes. Vitamin B12 supports neurological health and normal nervous system function, as well as the efficient production of red blood cells.
Nature Made B12 delivers 1,000 mcg of vitamin B12 and is made with an extended-release formula that extends the absorption rate of the essential vitamin. This supplement is gluten-free and contains no added colors, no artificial flavors, and no preservatives.
Vitamin B12 supplements are viewed as safe to consume by healthy individuals. They need to be taken as directed on the supplement label. If the consumed amount exceeds the directed, side effects may include headaches, nausea, vomiting, fatigue, weakness, and diarrhea.
Nature Made B12 is manufactured by the health supplements company Nature Made. This brand utilizes its private facilities that are located in California, United States to create and distribute its line of products. These facilities are FDA-recognized as they meet and exceed cGMP.
Nature Made is a trusted brand and their Vitamin B12 supplement is one of the most reasonably priced available. There are different forms available with varying serving sizes. The extended-release tablets cost a little more at $9.50 for a 50-count bottle.
Nature Made health products and supplements, including their vitamin B12 supplement, are sold by the majority of online and onsite retailers. These include the manufacturer's website and Amazon, as well as The Vitamin Shoppe, Walgreens, Walmart, CVS Pharmacy, GNC, Target, Costco, and Sam’s Club.


  1. O’Leary, F., & Samman, S. (2010). Vitamin B12 in health and disease. Nutrients, 2(3), 299-316.
  4. Piccoli, G. B., Clari, R., Vigotti, F. N., Leone, F., Attini, R., Cabiddu, G., ... & Avagnina, P. (2015). Vegan–vegetarian diets in pregnancy: danger or panacea? A systematic narrative review. BJOG: An International Journal of Obstetrics & Gynaecology, 122(5), 623-633.
  5. Elstgeest, L. E. M., Brouwer, I. A., Penninx, B. W. H., Van Schoor, N. M., & Visser, M. (2017). Vitamin B 12, homocysteine and depressive symptoms: a longitudinal study among older adults. European journal of clinical nutrition, 71(4), 468-475.
  6. Langan, R. C., & Goodbred, A. J. (2017). Vitamin B12 deficiency: recognition and management. American family physician, 96(6), 384-389.
  7. Mahmood, L. (2014). The metabolic processes of folic acid and Vitamin B12 deficiency. Journal of Health Research and Reviews, 1(1), 5.
  8. Jayedi, A., & Zargar, M. S. (2019). Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies. Critical reviews in food science and nutrition, 59(16), 2697-2707.
  9. Bottiglieri T. (1996). Folate, vitamin B12, and neuropsychiatric disorders. Nutrition reviews, 54(12), 382–390.
  10. Kannan, R., & Ng, M. J. M. (2008). Cutaneous lesions and vitamin B12 deficiency: an often-forgotten link. Canadian Family Physician, 54(4), 529-532.
  11. Brescoll, J., & Daveluy, S. (2015). A review of vitamin B12 in dermatology. American journal of clinical dermatology, 16(1), 27-33.
  12. Del Bo, C., Riso, P., Gardana, C., Brusamolino, A., Battezzati, A., & Ciappellano, S. (2019). Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial. Clinical Nutrition, 38(2), 575-583.

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