The Best Leaky Gut Supplements You Can Buy

Edited and medically reviewed by ✔️ Team of BestInSupplements | Written by Katelyn Johnson (B.S. and M.S. in Nutrition Science)

The best leaky gut supplements are designed to help the body strengthen the gastrointestinal tract’s lining and lower the level of inflammation in the body. Here you will find the best ones you can buy.

Best Leaky Gut Supplements

Leaky gut is a disorder that affects the integrity of the gut. As the body's first line of defense, the gut lining acts as a protective barrier that restricts and fights harmful toxins from entering the bloodstream 1. Many variables such as stress, poor diet, and weight problems can influence gut integrity.

The condition occurs as the result of a compromised gut lining developing holes and fissures which make your gut more susceptible to damage and triggers inflammation. This leads to toxins, partly digested food, and infectious bacteria seeping through the lining and into your circulation, which raises the risk of developing other health conditions 2. And here is where the best leaky gut supplements play a huge role.

Those who suffer from leaky gut may experience indigestion, lethargy, and decreased cognitive and physical endurance. Moreover, some of the most common gastrointestinal conditions, including irritable bowel syndrome, Crohn’s disease, and celiac disease, are due to a damaged gut lining 3.

Best Leaky Gut Supplements You Can Find In The Market

There are numerous health supplements available that can assist with leaky gut. An effective leaky gut supplement will work on regenerating the intestinal lining, while significantly improving and promoting gut health.

Although each leaky gut supplement is different, most benefit gut health in many ways. Some of these products contain natural compounds like digestion-supporting prebiotics and probiotics that improve and maintain a healthy gut microbiome, while others contain herbal extracts in high doses that have the ability to repair and restore the lining of the stomach 4.

With so many options, deciding which ones are worth the expense can be challenging. The following list contains the best leaky gut supplements you can buy.

Leaky Gut Revive

Leaky Gut Revive is a highly rated, quality leaky gut supplement. Utilizing a scientifically established formula of digestive boosting ingredients, it offers leaky gut sufferers an effective strategy to manage the condition's symptoms.

Review of Leaky Gut Revive

It was developed to reduce gut inflammation and strengthen gut permeability in order to prevent leaky gut. It contains glutamine, which aids in the restoration of the gut lining by assisting in the production of protein for cell reproduction 5. DGL (a type of licorice) aids in the formation of a healthy intestinal barrier, while marshmallow root acts as a protective barrier over the intestine lining.

With a formula backed by scientific findings, Leaky Gut Revive is ideal for every and any leaky gut sufferer. Thousands of satisfied customers agree that this supplement is a top contender.

Restore for Gut Health

Restore For Gut Health is a mineral supplement that can help with a variety of health issues. Gut balance is essential for general health and wellbeing. Gluten-rich, processed-food, and genetically modified-organism (GMO) diets have been shown to decrease bacterial health in the digestive system. This has ramifications for gastrointestinal, immunological, and general health.

Review of Restore for Gut Health

Every one of the ingredients used in Restore for Gut Health have been found to benefit digestive health,detox and metabolism, as well as support healthy respiratory, immunological, and cognitive functions.

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Terrahydrite, a unique substance that maintains intestinal wall permeability, is used in this supplement to help maintain a sustainable environment in which beneficial gut bacteria may develop and thrive.

Elm & Rye Probiotic

For those who believe they have a leaky gut but are new to the supplement community would benefit from supplementing with a powerful probiotic like Elm & Rye's.

Review of Elm & Rye Probiotic

Elm & Rye Probiotic contains natural ingredients that encourage and enhance a healthy functioning immune and digestive system. Elm & Rye is a trustworthy and socially responsible organization that strives to familiarize customers regarding the benefits of their sustainably sourced foods and products. In fact, Elm & Rye is committed to environmentally friendly manufacturing and distribution methods.

Their probiotic is free of fillers and additives, and their ingredients are also tested for purity and potency via independent third-party labs.

Total Reserve by Gundry MD

Gundry MD’s Total Reserve leaky gut supplement was developed to reinforce the lining of your gut. Nutrients such as glutamine, glucosamine, and magnesium accelerate gut cell replication, building an added protective layer on top of the stomach lining 5.

Review of Total Reserve by Gundry MD

Licorice, cinnamon, grape seed, and grapefruit are anti-inflammatory compounds that have the ability to restrict inflammatory responses that trigger digestive issues and stomach pain.

Because Total Reserve is formulated with research backed gut-promoting ingredients, as well as being a highly rated supplement, it qualifies as one of the best leaky gut products available to purchase on the market.

Seed Daily Synbiotic

Seed Daily Synbiotic is a 24-strain probiotic and prebiotic formulation designed to improve whole body health by optimizing both digestive and immunological health.

Review of Seed Daily Synbiotic

This powerful pre- and probiotic supplement restores digestive health, strengthens the gut barrier, and boosts gut immunity 6. In doing so, it effectively and efficiently reduces bloating and promotes regular bowel movements.

Seed Daily Synbiotic is distinctive in that it employs a two-in-one nested capsule, with prebiotics in the exterior portion of the capsule while the probiotics are in the interior portion of the capsule. This method of delivery shields the formula from digestive enzymes, gastric acidity, and bile salts, assuring that 100% of the contents reach your colon.

HUM Flatter Me

Flatter Me is formulated with a blend of 18 comprehensive ingredients, namely digestive enzymes, which are important compounds to support efficient breakdown of food and nutrients. This helps to alleviate bloating and enhance digestion 6.

Review of HUM Flatter Me

Additional digestive support is provided by ginger, peppermint leaf, fennel seed oil, and bromelain. These compounds help the body effectively break down food components such as protein, fats, carbs, and fiber.

Flatter Me is free of gluten, GMOs, and of artificial sweeteners and colors. Independent labs have also confirmed the supplement's efficacy, and it has been triple tested for purity.

Amen Leaky Gut+ by Codeage

Amen Leaky Gut+ provides the specialized treatment that your gut requires to heal and restore, allowing it to function at its healthiest. To enhance stomach and digestive health, this product contains a blend of prebiotics, probiotics, L-glutamine, and zinc 7.

Review of Amen Leaky Gut+ by Codeage

Other significant nutrients include a fermented sustainably sourced herbal blend formed from raw, organic apple cider vinegar, ginger root, and turmeric root. Amen Leaky Gut+ is free of dairy, GMOs, and gluten, and is manufactured in a facility that is cGMP certified.

Vital Restore by KaraMD

Vital Restore by KaraMD is a physician-formulated leaky gut supplement that supports a balanced gut microbiome environment in order to relieve and prevent leaky gut 6.

Review of Vital Restore by KaraMD

This potent formula contains five powerhouse ingredients, most notably glutamine and berberine, which are nutrients your body needs in order to naturally restore the gut wall’s mucosa lining. Vital Restore also features turmeric, slippery elm, and zinc, which are active compounds that help reduce inflammation 7.

Consumers experience weight loss, as well as improved mental clarity and happiness. KaraMD Vital Restore is free of gluten and GMOs. It's also vegan and manufactured in an FDA-approved facility in the United States.

Terra Origin Healthy Gut

Healthy Gut by Terra Origin is a dietary powdered leaky gut supplement designed to thicken and strengthen the walls and lining of the intestinal tract and stomach, as well as tighten the structure that holds the digestive tract together in order to prevent leaky gut 6. The goal of this leaky gut supplement is to repair and restore the destruction caused by toxins and bacteria, which can enter the bloodstream and trigger detrimental health effects within the body 7.

Review of Terra Origin Healthy Gut

Many of the top nutrients that benefit gut health are found in Terra Origin Healthy Gut. These include zinc, L-glutamine, glucosamine, licorice root extract, slippery elm bark powder, and marshmallow root. These compounds work together to strengthen and heal the intestines while also lowering intestinal permeability. They also activate nerves, causing mucus to be released and inflammation to be reduced 6,7.

Frequently Asked Questions

The best leaky gut supplements are designed to help the body strengthen the gastrointestinal tract’s lining and lower the level of inflammation in the body. They also help to relieve the common symptoms of leaky gut syndrome, including bloating, gas, cramping, pain, and food sensitivities.
The main ingredients found in leaky gut supplements will have antioxidant and anti-inflammatory properties. Common natural ingredients include collagen, berberine, zinc, glutamine, butyrate,deglycyrrhizinated licorice (DGL), probiotics, and curcumin. These nutrients have been shown to help with the symptoms of leaky gut syndrome and support gut health.
Choose a leaky gut supplement made with natural ingredients that have been shown to be effective in alleviating symptoms of leaky gut and support gut health. When choosing the best leaky gut supplement, buy from reputable brands that use clinically-proven dosages and scientifically-validated supporting claims.
The best leaky gut supplements are available to purchase in several different forms. They can be found in powder, tablet, capsule, or liquid forms. The effectiveness of the supplement does depend on the form, ingredients, and dosage. Capsule and powder are the most common forms for leaky gut supplements.
Avoid buying leaky gut supplements from brands that do not have a good reputation or make unsubstantiated claims about their products' benefits. It is also recommended that you avoid supplements with unnecessary fillers, ingredients, or additives as this decreases the effectiveness of the products’ active compounds.
Similar to all supplements, leaky gut supplements are not devoid of risk factors. Although the formula may be made with natural ingredients, there’s still a chance of experiencing side effects like digestive distress and nausea. These are sometimes common for the first few days of taking the supplement.


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  2. Vitetta, L., Vitetta, G., & Hall, S. (2018). The Brain–Intestinal Mucosa–Appendix–Microbiome–Brain Loop. Diseases, 6(2), 23.
  3. Camilleri, Á., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012). Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterology & Motility, 24(6), 503-512.
  4. Rawlings, D. (2013). Fermented Foods for Health: Use the Power of Probiotic Foods to Improve Your Digestion, Strengthen Your Immunity, and Prevent Illness. Fair Winds Press.
  5. Camilleri, M. (2019). Leaky gut: mechanisms, measurement and clinical implications in humans. Gut, 68(8), 1516-1526.
  6. Krishna Rao, R., & Samak, G. (2013). Protection and restitution of gut barrier by probiotics: nutritional and clinical implications. Current Nutrition & Food Science, 9(2), 99-107.
  7. Sturniolo, G. C., Di Leo, V., Ferronato, A., D’Odorico, A., & D’Incà, R. (2001). Zinc supplementation tightens “leaky gut” in Crohn’s disease. Inflammatory bowel diseases, 7(2), 94-98.

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